Pyelonephritis-like lesions as a late effect of diffuse intravascular coagulation.

A short episode of diffuse intravascular coagulation caused a range of severe kidney alterations in rabbits which did not die immediately with renal cortical necrosis. Histology resembled that of chronic pyelonephritis. The rabbits exhibited a steep but completely reversible rise in blood creatinine level, and ultimately no abnormalities of the urine. Blood pressure remained normal. It is supposed that comparable situations may arise in human pathology.