Amidate Prodrugs of O ‑2-AlkylatedPyrimidine Acyclic Nucleosides Display Potent Anti-Herpesvirus Activity
2020
Three
series of amidate prodrugs of O-2-alkylated
acyclic nucleosides of the 3-fluoro-2-(phosphonomethoxy)propyl (FPMP),
cyclic 3-hydroxy-2-(phosphonomethoxypropyl) (cHPMP), and 2-(phosphonomethoxypropyl)
(PMP)-type featuring cytosine and 5-fluorocytosine as nucleobases
were readily synthesized. Both the aspartic acid ester and valine
ester prodrugs of (R)-O-2-alkylated
FPMPC exhibited potent anti-HCMV and VZV activity in the micromolar
range. In addition, the valine ester prodrugs of 5-fluorocytosine
(R)-O-2-alkylated FPMP and (R)-O-2-alkylated cHPMPC showed inhibitory
activity at molar concentrations against these viruses.
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