Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines: a single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China.

Objectives: To compare immunogenicity among an inactivated hepatitis A vaccine (Healive®) with one-dose and two-dose regimens, and three kinds of live attenuated vaccines in children.Results: No significant differences were observed in seroconversion rates (seroprotection rates) among the five groups at 6 or 12 mo (p > 0.05). The geometric mean concentration (GMC) of anti-HAV IgG was significantly higher in the two-dose Healive® group than in the one-dose Healive® group and the attenuated vaccine groups at 12 mo (932.4 vs. 112.7, 135.8, 203.3, 212.8 mIU/ml, respectively, p 0.05). The GMCs were significantly higher in the 1–2 y of age group than in the 3–6 y of age group for all types of vaccines...