Bis(metoxybenzylaminoalkyl)amines with cardiotropic activity

FIELD: pharmacology. SUBSTANCE: invention relates to new bis(methoxybenzylaminoalkyl)amines of general formula (I) and their physiologically acceptable salts with cardiotropic activity. Due to their acute toxicity (LD 50 ), compounds belong to classes III and IV of toxicity. In the general formula (I), R 1 , R 2 , R 3 , R 4 may be two or three hydrogens, or one or two methoxy groups, n and m may be the same and have the values 2 or 3 or different and have the values n=2 and m=3. As the pharmaceutically acceptable salts of bis(methoxybenzylaminoalkyl)amines of general formula I, their trihydrochlorides of general formula II (I⋅3HCl) are preferred. Most preferred are trihydrochlorides selected from trihydrochloride N 1 -(2,5-dimethoxybenzyl)-N 2 -{2-[(2,5-dimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (IIc), trihydrochloride N 1 -(2,3,4-trimethoxybenzyl)-N 2 -{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (IId) and trihydrochloride N 1 -(2,4-dimethoxybenzyl)-N 3 -{3-[(2,4-dimethoxybenzyl)amino]-propyl}-1,3-propanediamine (IIf). EFFECT: compounds exhibit anti-ischemic and antiarrhythmic, in particular antifibrillatory, action. 14 cl, 5 tbl, 14 ex