Repair Activity Impaired by Arsenic: Recovery by Phytochemicals

Cancer burden all over the world is on the rise. Carcinogenesis is not a single process, but involves multitude of mechanisms. Three main three steps are initiation, promotion and progression, which act in concert to contribute to the malignant transformation. Oxidative stress plays a pivotal role in the initiation of the events. Enhanced generation of Reactive Oxygen Species (ROS) can originate from exogenous sources like environmental agents, pharmaceuticals, industrial chemicals etc. However endogenous sources like mitochondria, peroxisomes, and inflammatory cell activation can have equal contribution in this regard (Klaunig et al., 2010). They can affect the intrinsic antioxidant defence mechanism of the cell which is insufficient to overcome the ROS burden. ROS production disrupting the ISSN: 2319-7706 Volume 4 Number 3 (2015) pp. 578-587 http://www.ijcmas.com