Lipin and glucolipid metabolism

The expression product of lipin is a group of intracellular protein.Lipin acts as a transcriptional coactivator that amplifies the effect of coactivators on transcription of triglyceride synthesis and the key enzymes synthesis of gluconeogenesis.Lipin is expressed at high levels in metabolically active tissues and organs such as adipose tissue,skeletal muscle,liver and hypothalamus.Lipin family,including lipin 1,lipin 2 and lipin 3,can regulate lipid metabolism bidirectionally.Lipin is also closely associated with insulin resistance and abnormal glucose metabolism.So lipin may be a new periphery target in the treatment of obesity and glucolipid metabolism related diseases. Key words: Lipin;  Lipid metabolism;  Insulin resistance