[Efficacy observation of Guan's quadruple therapy for kidney disease on the treatment of chronic renal failure].

Objective To compare the differences in the clinical efficacy between Guans quadruple therapy for kidney disease and the conventional western medication in the treatment of chronic renal failure(CRF).MethodsEighty patients were randomized into an observation group and a control group,40cases in each one.In the observation group,besides the physician instruction of low protein and low phosphorus diet in the two groups,Guan's quadruple therapy for kidney disease was applied,including①the isolated herbal moxibustion at Shenshu(BL 23)and Pishu(BL 21),or Ganshu(BL 18),Zusanli(ST 36)and Guanyuan(CV 4)alternatively;②acupuncture at the auricular points such as shen(CO10),jiaogan(AH6),Shenshangxian(TG2),fei(CO14)and pizhixia(AT4);③injection of mixture of astragalus injection and lidocaine injection at Feishu(BL 13),Pishu(BL 21),Shenshu(BL 23)and the others;④ modified Shenshuai Yihao decoction according to syndrome differentiation.In the control group,the conventional western medication was used.After 6months of treatment,the differences were observed between the two groups in the clinical efficacy,serum creatinine(Scr),blood urea nitrogen(BUN),endogenous creatinine(Ccr)and 24hurine protein quantitation(UPQ).Results In the observation group,after treatment,the remarkably effective rate was 50.0%(20/40)and the total effective rate was 82.5%(33/40),which were superior to 25.0%(10/40)and 45.0%(18/40)in the control group(both P0.05).After treatment,the levels of Scr,BUN and 24hUPQ were reduced apparently(all P0.05),and the level of Ccr was increased apparently in the two groups(both P0.05).After treatment,the levels of Scr,BUN and 24hUPQ were reduced much more apparently in the observation group as compared with those in the control group(all P0.05).Conclusion Guan's quadruple therapy for kidney disease achieves a better efficacy on CRF compared with the conventional western medication.This therapy improves renal functions,relieves clinical symptoms and physical signs and benefits the life quality of patients.