Flow Cytometric DNA Analysis in Fine Needle Aspiration Biopsies from Patients with Prostatic Lesions. Diagnostic Value and Relation to Clinical Stages

Transrectal fine needle aspiration biopsy was carried out in 59 patients with cancer of the prostate, benign prostatic hypertrophy and prostatitis for cytomorphological examination and flow cytometric DNA analysis. One major single peak in the DNA histogram was observed in patients with benign hyperplasia, prostatitis and in some patients with carcinoma. A DNA histogram with a second or third peak was always compatible with carcinoma and was found both in patients with carcinoma in stage I-II and stage III-IV. It is suggested that patients with hyperploid cancers in stage I-II could benefit from early treatment.