Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis y HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reducatse inhibitors, pravasattin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice., All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.005 and 0.001% levels in drinking water, and Si at 0.01 and 0.002% levels in the diet. All animals had access to Pr or Si throughout the experiments which were terminated at weeks 25 or 30. Histologically most of the tumors were welldifferentiated adenocarcinomas