Confusion After Topical Use of Resorcinol

Resorcinol, in low concentrations (1% to 2%), is included in many antiseptic and keratolytic topical medications. It is sometimes used at higher concentrations as a peeling agent (a peeling paste usually contains 40% of the drug) for the treatment of acne vulgaris. 1 Systemic effects of resorcinol are similar to those of phenol, particularly on the central nervous system. We report a case of confusion after percutaneous absorption of resorcinol with positive rechallenge. Report of a Case. A 28-year-old woman without a neurologic history was treated for 3 days for acne vulgaris involving the entire back with the following preparation: resorcinol, 80 g; axonge benzoin, 56 g; colloidal silica, 4 g; and zinc oxide, 20 g. This paste was a magistral preparation dispensed by her pharmacist. Following each of three applications, she presented with confusion, postcritical amnesia, and tremors; she was disoriented and had vacant stare, but no clonism. Rechallenge