Malathion administration: Effects on physiological and physical performance in the heat ☆

To determine the effects of low-dosage organophosphate administration on exercise in a hot environment, malathion (7.5 mg/day, 4 days) was administered IP to rats, and effected a 35% (p<0.01) reduction in plasma cholinesterase levels. Treadmill endurance (9.14 m/min, no incline, 35°C ambient) was unaffected when the animals were exercised by hyperthermic exhausion (Tre≈43°C). While rates of heat gain were similar between groups, malathion-treated rats displayed higher Tsk (p<0.05) at a number of sampling times during the treadmill run. While creatine phosphokinase levels were unaffected by either cholinesterase inhibition or exercise in the heat, lactate dehydrogenase activities were increased (p<0.01) in both groups following hyperthermic exhaustion. Althougt plasma levels of lactate, potassium, urea nitrogen, and creatinine were all significantly (p<0.01) increased as a result of exercise in the heat, these increments were not exacerbated by cholinesterase inhibition. Results generally indicated that at this moderate level cholinesterase inhibition, malathion administration did not adversely affect physiological, physical, or thermoregulatoryu efficacy.