Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats

Kalyan N. Rao,Alena M. Sentir,Eric A. Engleman,Richard L. Bell,Leslie A. Hulvershorn,Alan Breier,R. Andrew Chambers

Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats

2016

Kalyan N. Rao
Alena M. Sentir
Eric A. Engleman
Richard L. Bell
Leslie A. Hulvershorn
Alan Breier
R. Andrew Chambers

Rational Prefrontal cortical (PFC)–hippocampal–striatal circuits, interconnected via glutamatergic signaling, are dysfunctional in mental illnesses that involve addiction vulnerability.

Keywords:

Self-administration
Nicotine
Schizophrenia
Radial arm maze
Lesion
Hippocampal formation
Sensitization
Addiction vulnerability
Anesthesia
Pharmacology
Psychology

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