Effect of a β2-Sympathomimetic on Gastrin Release, Acid Secretion, and Blood Glucose During Basal Conditions and in Response to Insulin, 2-Deoxy-D-Glucose, and Feeding in the Dog

The effect of a selective β2-adrenoceptor agonist on basal volume and on insulin-, 2-deoxy-D-glucose (2-DG)-, and food-induced gastrin release was studied in conscious gastric fistula dogs. Acid output and blood glucose changes were also studied, except in the food experiments. Basal acid secretion and serum gastrin were unchanged after β2-sympathetic infusion, whereas a slight increase in blood and glucose was found. The β2-agonist almost prevented acid output and gastrin release after insulin hypoglycaemia. However, the hypoglycaemia was also inhibited. Gastric acid secretion stimulated by 2-DG was inhibited, as was probably the gastrin release. 2-DG increased the blood glucose level, and no significant differences were found after β2 infusion. After feeding, gastrin release was initially decreased for one of five doses of the β2-agonist, and higher doses of the β2-agonist prevented the subsequent fall in serum gastrin after the initial peak value. This pattern was also found for the histamine H2-blocke...