Modulation of vascular tone control under isometric muscular stress: Role of estrogen receptors

2013 
Abstract Aims The aim of this study was to evaluate isometric muscle contraction (handgrip) changes on key elements of cardiac afterload, before and after raloxifene administration in postmenopausal women. Methods/results 12 postmenopausal and 12 fertile women were studied. Postmenopausal women underwent raloxifene administration (60 mg/day for 30 days). We evaluated vascular reactivity in superficial palmar arterial arch during handgrip in postmenopausal women before and after (M + R) drug administration, and in controls. Blood flow was higher after raloxifene administration (p  Conclusions Raloxifene reduced the vascular effects of isometric muscle contraction by modulating the vasomotor tone of peripheral vessels in relation to exercise.
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