In vitro combined effects of cefteram with ampicillin, cefaclor and minocycline.

In vitro combined effects of cefteram, an active metabolite of cefteram pivoxil, with ampicillin, cefaclor or minocycline against Escherichia coli NIHJJC-2, Staphylococcus aureus FDA 209P or Methicillin Resistant Staphylococcus aureus (MRSA) were examined by checkerboard dilution method.The combined use of cefteram and ampicillin showed an apparent synergistic antimicrobial action against eight strains in ten of MRSA.The combined use of cefteram and cefaclor also showed an apparent synergistic action against three strains in ten of MRSA and a partial synergistic action against six strains in ten of MRSA, while the combined use of cefteram and minocycline showed a partial synergism against nine strains in ten of MRSA.The combined use of cefteram and ampicillin, cefaclor or minocycline observed a synergistic action against Staphylococcus aureus FDA 209P, but no synergistic action against Escherichia coli NIHJJC-2.