Aqueous HumorTransforming Growth Factor-E2 Level in Patients with and without Posterior Capsule Opacity After Congenital Cataract Surgery

Although microscopic operation technique improves pediatric cataract surgery results, posterior capsule opacification (PCO)remains the most common complication after congenital cataract surgery. Histology of PCO has been known, but the underlying cellularmechanisms remain unclear. Recently the role of cytokines present in the anterior segment after cataract surgery was investigated, suchas TGF-E2. TGF-Econtrols the differentiation of various types of cells.TGF-Ealso induces cataractogenesis. Laboratory studies showedthat in high level of TGF-E2, PCO occur more easily. The aim of this study is to determine the differences of aquoeus humor TGF-E2level in patients with and without posterior capsule opacity after congenital cataract surgery. The design of study was cross-sectional,and population target is all congenital cataracts that were underwent cataract surgery by using intraocular lens (IOL) in the bag,and without primary posterior curvilinear capsulorexis (PPCC) in Sarjito Hospital Yogyakarta and Dr Yap Eye Hospital Yogyakarta.This study revealed mean TGF-E2 level in the group with PCO was 259.91 (± 63.45) pg/ml and in the group without PCO was 225.81(± 121.26) pg/ml. The difference of TGFE2 level in the group with PCO and without PCO is not significant