A kind of preparation method of ethanesulfonic acid Nintedanib

The present invention relates to a kind of preparation methods of ethanesulfonic acid Nintedanib, include the following steps: step 1: 1- acetyl group -3- [methoxyl group (phenyl) methylene] -2- oxoindoline -6- methyl formate (compound A) and N- (4- aminophenyl)-N being added in reaction dissolvent, 4- dimethyl -1- piperazineacetamide (compound B) reaction, having reacted addition pyrrolidines, the reaction was continued, crystallization, mixed solvent, which stirs, to be washed, it is dry, generation (3Z) -3- [(4- methyl-[(4- methylpiperazine-1-yl) acetyl group] amino) and phenyl) amino]-(phenyl) methylene } -2- oxo -2, 3- indoline -6- methyl formate (compound C)；Step 2: compound C is reacted with ethanesulfonic acid, crystallization, filtration drying, is generated ethanesulfonic acid Nintedanib (compound D).The present invention obtains purity is high, the ethanesulfonic acid Nintedanib that yield is good, impurity level is low by two-step reaction.