Apoptosis in blood diseases Review - new data

In this report we reviewed the recent data regarding the involvement of apoptosis or progammed cell death in hematological diseases. We summarized new features of apoptosis including high molecular weight DNA fragmentation and programmed cell death of enucleated cells. We described the recent contributions about the three oncogenes bcl-2, p53 and c-myc. New inducers and inhibitors of apoptosis have been reported, particularly the role of stromal environment, thrombopoietin, erythropoietin and flt-3 ligand has been mentioned.