Effects of Tirofiban combined with thrombus aspiration on myocardial reperfusion and no-reflow after percutaneous coronary intervention in elderly patients with ST-segment elevation myocardial infarction

Objective To investigate the effects of Tirofiban combined with thrombus aspiration on myocardial reperfusion and no-reflow after percutaneous coronary intervention(PCI)in elderly patients with ST-segment elevation myocardial infarction(STEMI). Methods A total of 185 patients with STEMI were randomly divided into a control group(n=93)and a study group(n=92). The control group received direct stenting or percutaneous coronary angioplasty before stent placement.The study group received an intracoronary injection of Tirofiban 10 μg/kg, thrombus aspiration, and then balloon dilatation or direct coronary stenting.Postoperative recovery was compared between the groups, and major adverse cardiovascular events(MACE)were recorded. Results The incidence of no-reflow, the thrombolysis in myocardial infarction, the corrected(TIMI)frame count(CTFC)and the peak of plasma creatine kinase MB isoenzyme(CK-MB)were lower in the study group than in the control group[(no reflow, 8 cases or 8.7% vs.21cases or 22.6%, χ2=6.752, P 0.05). Conclusions Tirofiban combined with thrombus aspiration can improve myocardial reperfusion in elderly patients with STEMI after PCI, and has excellent clinical value. Key words: Myocardial infarction; Angioplasty, transluminal, percutaneous coronary; Myocardial reperfusion; No-reflow phenomenon