Aquaporin-5, Subunit Beta in the Sodium Channel Epithelium, Lung Ultrasonography Examination in Transient Tachypnea of the Newborn

Studies have identified several isoforms of aquaporin that expressed in many types of cells and located in different locations in human body. Aquaporin plays an important role in water regulation system by providing the water channels to facilitating water transport through the barriers. In neonates, aquaporin helps pulmonary fluid clearance as quick as after the birth time by absorption mechanism to allows the air exchange normally and avoid the respiratory distress as in transient tachypnea of the newborn (TTN). Subunit beta in the sodium channel epithelium also plays a role in respiratory distress of the newborn. Some pathological condition affect the aquaporin expression. Study showed that aquaporin 5 expression was higher in TTN group than the control and respiratory distress syndrome group. The primary findings of lung ultrasonoghraphy in diagnosing TTN are double lung point and alveolar intersisial syndrome.