Effect of piper tuberculatum extract on adult schistosoma mansoni: in vitro and in vivo tests

Schistosomiasis is a severely neglected disease with a wide geographical distribution. It affectsapproximately 210 million people in the world and at least 800 million people live in risk areas.The search for new drugs to treat this parasitosis is significant due to the appearance of strains of theworm that are resistant to the currently available drugs. The retrieval of compounds extracted fromplants that act on these parasites has increased scientific investigation of this subject. The presentstudy demonstrates, in vitro and in vivo, the action of crude extract of Piper tuberculatum on adultSchistosoma mansoni. The extract was shown to be quite effective in the in vitro tests, causing softtissue alterations and acting on the reproductive system of females and the mortality of the worms,with a greater effect on males. The in vivo experiment was performed with infected Mus musculusand a decrease in the number of eggs in the first and second oogram stages was found, suggestingaction on oviposition...(AU) A esquistossomose, doenca negligenciada grave e de larga distribuicao geografica, atinge cerca de210 milhoes de pessoas no mundo e ao menos 800 milhoes vivem em area de risco. A busca de novosmedicamentos para o tratamento desta parasitose e relevante em razao do aparecimento de linhagensdo verme resistentes aos farmacos disponiveis. A obtencao de compostos extraidos de plantas comacao sobre parasitos tem incrementado a investigacao cientifica sobre este assunto. O presentetrabalho mostra a acao in vitro e in vivo do extrato bruto de Piper tuberculatum sobre adultosde Schistosoma mansoni. O extrato mostrou-se bastante eficaz nos ensaios in vitro, provocandoalteracoes tegumentares, tendo acao no sistema reprodutor das femeas e na mortalidade dos vermes com maior acao sobre os machos. Como resultado em experimentos in vivo, realizados em Musmusculus infectados, observou-se a diminuicao do numero de ovos de 1o e 2o estagios em oogramas,o que sugere uma acao na postura de ovos...(AU)