peroxide has a role in the aggregation of human platelets

The aggregation of platelets induced by soluble and particulate stimuli is enhanced by the addition of minute amounts of HZOZ. Externally added catalase strongly inhibits the aggregation induced by particulate stimuli and by phorboi myristate acetate (PMA). The addition of aminotriazole to stimulated platelets causes a significant inhibition of intracellular catalase. This indicates the formation of H,O, inside the platelets during activation. No effects were observed when the platelets were stimulated by the ionophore A23 187.