Clinical characteristics of patients with chronic renal insufficiency in different degree and coronary heart disease combined with changes of creatinine levels before and after PCI

Objective To investigate the clinical characteristics of patients with chronic renal insufficiency and coronary heart disease(CHD) and the changes of creatinine levels before and after PCI. Methods A total of 102 patients with chronic renal insufficiency underwent coronary intervention were followed up for at least one month. The changes of creatinine levels were analyzed. Renal insufficiency degrees were divided into mid group, moderated group and severe group by serum creatinine levels. The patients with mild renal insufficiency (group 1) were treated with hydration before and after PCI. Besides hydration, the patients in moderate renal insufficiency group (group 2)were given shenkang injection, Haikun Shenxi capsule, Ketosteril and so on to improve kidney function; the patients in severe renal insufficiency group (group 3) were treated with hemodialysis besides hydration and drugs like group 2. Results The proportion of males was high in different degrees of renal dysfunction cornbined with coronary heart disease. The general data showed no significant difference. The severe renal insufficiency group had younger age, and the moderate and severe renal insufficiency group had high proportion of three vessels lesions the midl group had high proportion of double vessels disease. A total of 101 patients successfully completed the interventional procedures, 2 patients with severe renal insufficiency died in intraoperation and postoperative 2 days. There were 3 patients suffered from contrast-induced nephropathy(CIN). One month later, creatinine had no significant difference compared with those before hospitalization. Conclusions To improve renal function before PCI for patients with varying degrees of chronic renal insufficiency, can make the patients better tolerate PCI. Key words: Different degree; Chronic renal insufficiency; Coronary heart disease; Percutaneous coronary intervention; Creatinine