Barbiturates: A Review of Synthesis and Antimicrobial Research Progress.

BACKGROUND Barbituric acid and its derivatives have turned heads for several years as an indispensable class of compounds in the pharmaceutical industry because of their vast assortment of biological activities such as anticonvulsants, hypnotics, anti-diabetic, antiviral, anti-AIDS, anti-cancer, anti-microbial and anti-oxidant etc. Plethoras of studies have shed light on the properties, synthesis, and reactivity of these compounds. The depiction of multiple biological activities by barbiturates compelled us and by virtue of which herein we have mediated over the progress of synthesis of numerous kinds of compounds derived from barbituric acid with well-known and typical examples from 2016 to the present. OBJECTIVE The review focuses on the advancements in methods of synthesis of barbituric acid derivatives and their applications as antimicrobial agents. CONCLUSION This review will help future researchers to analyze the previous studies and to explore new compounds for the development of efficient antimicrobial drugs.