Abnormal auditory mismatch fields in adults with autism spectrum disorder

Abstract The auditory mismatch field (MMF) is a pre-attentive processing component, reflecting neural discrimination and inhibitory processing. Abnormal MMFs have been reported in children with autism spectrum disorder (ASD) along with an association with abnormal language comprehension; however, relatively little is known about MMF abnormalities to contrasting vowel stimuli in adults with ASD. To better understand the neurophysiological mechanisms underlying auditory language discrimination of vowel stimuli in individuals with ASD, magnetoencephalography was used to measure MMFs during an auditory oddball paradigm with vowel stimuli (/a/ and /u/) in adults with ASD. MMFs arising from left and right superior temporal gyrus are reported from nine high-functioning right handed males with ASD (22.22 ± 5.74yrs) and sixteen typically developing (TD) right handed males (27.25 ± 6.63yrs). The MMF was delayed in adults with ASD (188.90 ± 5.8 ms) as compared to the TD participants (173.08 ± 4.31 ms, p