Defective Solubilization of Immune Complexesand Activation of the Complement Systemin Patients with Pulmonary Tuberculosis
2009
Introduction Association between inherited deficiencies of
the complement components and immune complex disease
indicates the importance of the complement system in the
handling of circulating immune complexes. High levels of
circulating immune complexes are seen in pulmonary
tuberculosis. This study is, therefore, aimed to look at the
concentration of circulating immune complexes, the status of
complement-mediated immune complex handling, and the
extent of complement activation in untreated pulmonary
tuberculosis compared to treated pulmonary tuberculosis
patients and healthy controls.
Results High immune complex levels, decreased complementmediated
solubilization, and increased activation of the
complement system were observed in untreated tuberculosis
patients.
Conclusions The results obtained from the present study
suggest that complement mediated solubilization is less in
patients with tuberculosis, and this defective solubilization
is likely to take part in a vicious cycle involving immune
complex deposition and complement activation and, thus,
may lead to disease progression depending on the nature of
the defect.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI