Synthesis and anti-bacterial, anti-fungal activity of novel 1,2,4-oxadiazole
2011
A series of novel 1, 2, 4-oxadiazole derivatives were synthesized and evaluated for in- vitro
antibacterial and antifungal activity. All the compounds tested against bacteria showed
comparable or less antibacterial activities than the reference drug. Differences in their activity
depend on the substitution of different groups. More specifically, best antibacterial activity
among synthetic analogues was shown by compound 6 with MIC of 10 I¼g/ml and compound 14
with MIC of 50 I¼g/ml against Bacillus subtilis. All compounds tested showed significant
antifungal activity against all the fungi, compared to the commercial fungicide Miconazole.
Among them compounds 4 and 8 showed good antifungal activity against Fusarium solani with
MIC of 10 and 50 I¼g/ml
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