lar Cardiomyocytes: A Key Role For Caspase-8 Activation

Theraptosis S.A., Romainville,France.Tumor necrosis factor a (TNFa), a pro-inflammatory cytokine, is associatedwith major cardiomyopathy. In the heart, TNFa binding to the TNF receptor1 (TNFR1) has been implicated in TNFa mediating negative inotropic effectsaswellasapoptosis.TNFa-TNFR1activatescaspase-8whichleadstocaspase-3 activation either directly or following mitochondrial disruption. Here we in-vestigated whether caspase-8-induced mitochondrial dysfunction could lead toTNFa-induced alterations of Ca