PARP-1 modulates β1-integrin/NF-κB-mediated radioresistance in human breast cancer

David Raleigh,Kazi M. Ahmed,Hui Zhang,Shabnam Ziaee,Catherine C. Park

PARP-1 modulates β1-integrin/NF-κB-mediated radioresistance in human breast cancer

2016

David Raleigh
Kazi M. Ahmed
Hui Zhang
Shabnam Ziaee
Catherine C. Park

Abstract Genomic damage triggers a signal transduction network that modulates gene expression and protein stability to repair DNA and influence cell survival. Inhibition of the DNA damage response protein PARP-1 is the subject of

Keywords:

Radioresistance
Gene expression
DNA
Tumor microenvironment
Poly ADP ribose polymerase
DNA damage
Cancer research
Signal transduction
Molecular biology
NF-κB
Biology
Cancer
Chemistry

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