Patient self-evaluation of side-effects related to adjuvant chemotherapy in breast cancer: A prospective study.

9606 Background: There is a growing interest in patient-reported outcomes (PRO) in cancer treatment. We evaluated a Common-toxicity criteria (CTC) v4.02-based, self-administered questionnaire to collect 10 common chemotherapy-related side effects (CSE) in patients (pts) undergoing standard adjuvant chemotherapy (ACT) for operable breast cancer. Methods: In this prospective study, 610 pts at 11 sites were administered the questionnaire after the first and the third cycle of ACT. For each item (nausea, vomiting, constipation, anorexia, taste alterations, diarrhea, fatigue, pain, neuropathy and dyspnea) the CTC v4.02 definitions of grade of severity were translated into Italian and rephrased. Pts were asked to choose the definition that best represented the worst CSE experienced after ACT. At each time/point, information on CSE was extracted from the medical charts to compare pts- vs doctors (drs)-reported CSE. Results: 596 and 581 questionnaires were collected after cycle 1 and cycle 3 of ACT. A median of 8...