Abstract 17161: Reduced Ventilatory Function and Gas Exchange are Associated With Cardiac Remodeling and Changes in Systolic and Diastolic Function in the Community

Introduction: Chronic lung disease and heart failure have been reported to be associated, but the pathophysiologic relations between cardiac and pulmonary structure and function in the community are not well understood. We evaluated cross-sectional associations between measures of pulmonary function and echocardiographic traits related to cardiac remodeling and systolic and diastolic function in a large, community-based sample. Hypothesis: We hypothesized that lower ventilatory function and diffusion capacity would be associated with adverse cardiac remodeling and reduced left ventricular (LV) systolic and diastolic function. Methods: Forced expiratory volume in 1 second (FEV1), single-breath carbon monoxide diffusion capacity (DLCO), and comprehensive echocardiographic measures were obtained in approximately 2500 participants (mean age 67±9 years; 55% women) attending the 8th Framingham Offspring examination cycle. Results: Using multivariable-adjusted linear regression models, we observed lower DLCO to ...