Homoallylic amines as efficient chiral inducing framework in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines

The diastereoselective conjugate addition of secondary homoallylamines, obtained in the enantioenriched form via allylmetallation of imines, onto α,β-unsaturated esters is reported. Leading to tertiary amines bearing two chains integrating a stereogenic center adjacent to the Nitrogen, this method allows the access to valuable building blocks as well as heterocyclic skeletons.