Особенности функции щитовидной железы у пациентов с гастроэзофагеальной рефлюксной болезнью

120 patients with different stages of gastroesophageal reflux disease (GERD) and 25 persons of control group were studied. Structure and volume of the thyroid gland were estimated by ultrasound investigation. Radioisotope method was used to determine levels of thyroxine, triiodthyronin, thyriotropic hormone and titer of antibodies to thyreoglobulin. The results analyzed suggested some new pathogenetic mechanisms of development of GERD. The decreased level of iodthyronin in all stages of the disease confirmed disturbance in the work of low esophageal sphincter in hypofunction of thyroid gland. Secondly, the direct harmful effects on smooth muscle of esophageal sphincter by autoantibodies to thyreoglobulin were not excluded. Titer of autoantibodies to thyreoglobulin proved to be increased in all patients with GERD and accelerated depending on the stage of the disease.