Hyperreflexia induced by XLR-11 smoke is caused by the pyrolytic degradant

Purpose Some of the synthetic cannabinoids, often found in recreational drugs of the herbal form, reportedly induce a generalized seizure in drug abusers immediately after smoking. However, it is still unclear what elicits the sensorimotor responses, particularly in the case of hyperreflexia or excitatory behavior during the synthetic cannabinoid exposure. The purpose of this study was to explore the mechanism underlying the hyperreflexia induced by smoke intoxication of XLR-11 [(1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone].