Characterization of a Synthetic Anionic Vector for Oligonucleotide Delivery Using in Vivo Whole Body Dynamic Imaging

Bertrand Tavitian,Stéphane Marzabal,Valerie Boutet,Bertrand Kuhnast,Salvatore Terrazzino,Marinette Moynier,Frédéric Dollé,Jean Robert Deverre,Alain R. Thierry

Characterization of a Synthetic Anionic Vector for Oligonucleotide Delivery Using in Vivo Whole Body Dynamic Imaging

2002

Bertrand Tavitian
Stéphane Marzabal
Valerie Boutet
Bertrand Kuhnast
Salvatore Terrazzino
Marinette Moynier
Frédéric Dollé
Jean Robert Deverre
Alain R. Thierry

Purpose. To compare the pharmacokinetics and bioavailability of an oligonucleotide delivered in a free form or using cationic or anionic synthetic carrier systems.

Keywords:

Oligonucleotide
Cationic polymerization
Drug carrier
Liposome
In vivo
Bioavailability
Immunology
Chemistry
Molecular biology
Chromatography
Pharmacokinetics
Biophysics
Pathology
Dosage form

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