Lipase-ctalysed kinetic resolution of N,O-diacetyl-2-amino-1-butanol in diisopropyl ether.

Abstract N,O-Diacetyl-2-amino-1-butanol ( 2 ) on lipase-catalysed transesterification with 1-butanol in diisopropyl ether gave ( S )-(−) − 2 and ( R )-(+)-N-acetyl-2-amino-1-butanol ( 3 ); proper stereochemistry and correct optical rotations of chiral 2 and 3 , incorrectly reported in literature, were determined after their conversion to chiral 2-amino-1-butanol ( 1 ).