DEVICE CLOSURE VERSUS MEDICAL THERAPY ALONE FOR PATENT FORAMEN OVALE IN PATIENTS WITH CRYPTOGENIC STROKE: AN UPDATED COMPREHENSIVE META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Epidemiologic studies suggest that patent foramen ovale (PFO) is associated with cryptogenic stroke, especially in younger patients. However, three early randomized controlled trials (RCTs) failed to prove the superiority of PFO closure compared to medical therapy alone. One of the main limitations