Self-nanoemulsifying drug delivery system of fisetin: Formulation, optimization, characterization and cytotoxicity assessment

Abstract Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited oral bioavailability that reduces its therapeutic efficacy. In order to overcome this issue self-nanoemulsifying drug delivery system (SNEDDS) of fisetin were formulated and characterized for droplet size, shape, zeta potential, cell viability, dissolution and permeability studies. Prepared SNEDDS (1.2 mL) were composed of castor oil (0.1 mL), Lauroglycol FCC (0.1 mL), tween 80 (0.4 mL), Transcutol P (0.6 mL) and fisetin (5 mg). The formulation was optimized using Box Behnken Design. Droplet size and zeta potential of optimized SNEDDS were found to be 154 nm and −37 mV. Dissolution rate of fisetin got significantly (p