Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma

Andréia Hanada Otake,Ana Lúcia Mattar,Helano Carioca Freitas,Camila Maria Longo Machado,Suely Nonogaki,Clarice Kazue Fujihara,Roberto Zatz,Roger Chammas

Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma

2010

Andréia Hanada Otake
Ana Lúcia Mattar
Helano Carioca Freitas
Camila Maria Longo Machado
Suely Nonogaki
Clarice Kazue Fujihara
Roberto Zatz
Roger Chammas

Purpose We evaluated the involvement of angiotensin II (AngII)-dependent pathways in melanoma growth, through the pharmacological blockage of AT1 receptor by the anti-hypertensive drug losartan (LOS).

Keywords:

Losartan
Angiogenesis
Angiotensin II
Melanoma
Pharmacology
Angiotensin receptor
Angiotensin II receptor type 1
Neovascularization
Renin–angiotensin system
Medicine

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