Kinetic and dynamic interactions of oral viqualine and ethanol in man.

We have studied the interaction of viqualine, a 5-hydroxytryptamine (5-HT) uptake inhibitor, with ethanol in 16 healthy men aged 20 to 34 years. The subjects were randomly assigned to receive ethanol dosed to maintain blood alcohol concentrations of 17–22 mmol · l−1 (n=8) or orange juice (n=8) on each of two test days one week apart and preceded, in random order, by 3 days of viqualine 75 mg bd or placebo.