Recent novel tumor gatekeepers and potential therapeutic approaches (2017)

Tumor remains a challenging task for oncology community. Drug resistance due to chemotherapy remain principal impediments  toward potential therapeutic strategies. Development of novel anti-cancer drugs or new targeted strategies to conquer drug  resistance is a key goal of cancer research. In this respect, novel tumor gatekeepers and innovative targeted strategies can be  helpful in overcoming drug resistance as well as improve currently used targeted therapies. In this review, efforts have been made to present some of the latest knowledge about novel tumor gatekeepers and new therapeutic strategies to improve the efficacy of  chemotherapy and give new hope to cancer patients to fight against cancer. Keywords : Cancer, Potent inhibitors, Gatekeepers, Therapeutic approaches, Oncogenic pathways