Influence of Prolactin on Th1/Th2 Cytokines Parasecretion in SLE

The pathogenesis of systemic lupus erythematosus(SLE) is extremely complicated,which involved multifactorial interaction. As the knowledge about neuroendocrine-immune network has been further under stood: Evidences accumdated that prolactin (PRL) plays a role in the pathogenesis of many autoimmune diseases,such as SLE, rheumatoid arthritis, Sjgren's syndrome etc. Among them the relation-ship between PRL and SLE is remarkable.However, the exact mechanism on the pathogenesis of SLE remains elusive. PRL functions similarly to cytokine and plays an important role in the cytokine network. PRL acts in a paracrine and autocrine manner,which has an effect on the production of other cytokines.The relationships between SLE and Th1/Th2 cytokines parasecretion,PRL and Th1/Th2 cytokines parasecretion, and SLE and PRL had been reviewed in the paper.