Quartz crystal microbalance for telomerase sensing based on gold nanoparticles induced signal amplification

A novel circulating-flow quartz crystal microbalance (QCM) biosensing method has been established to detect telomerase. Oligonucleotide-functionalized gold nanoparticles (GNPs-cDNA) have been used to amplify the frequency change, which make this QCM to be a sensitive biosensor for telomerase activity detection, The detection limit was as low as 37 cells/mL. The assay platform exhibited excellent selectivity.