Expression Quantitative Trait Loci Analysis in Multiple Tissues

Expression quantitative trait loci (eQTL) analysis identifies genetic variants that regulate the expression level of a gene. The genetic regulation may persist or vary in different tissues. When data are available on multiple tissues, it is often desired to borrow information across tissues and conduct an integrative analysis. Here we describe a multi-tissue eQTL analysis procedure, which improves the identification of different types of eQTL and facilitates the assessment of tissue specificity.