Talaromyces thermophilus derived lipase mutant and application thereof

The invention discloses a talaromyces thermophilus derived lipase mutant with the amino acid sequence shown in SEQ ID No.2, and the lipase mutant is obtained by mutation of serine at the 83th-site of the amino acid sequence shown in SEQ ID No.2 into threonine, or mutation of serine at the 58th-site of the amino acid sequence shown in SEQ ID No.2 into methionine while mutation of serine at the 83th-site of the amino acid sequence shown in SEQ ID No.2 into threonine; the activity of the talaromyces thermophilus derived lipase mutant is 2-5 times of the parent activity, and the talaromyces thermophilus derived lipase mutant can be used for industrial production of (3S)-2-carboxyethyl-3-cyano-5-methyl hexanoic acid for further synthesis of pregabalin.