Determinación químico-analítica de Carbamazepina en un servicio antitóxico. Presentación de caso

The drugs of narrow therapeutic margin constitutes one of the involuntary main causing chemical agents of exogenous intoxications type, one of the most common is the Carbamazepine.  The clinical case describes a 7 years old male patient, which presented convulsions, hypotension, hypothermia and coma. At the admission moment in the hospital was considered the practice of the toxicological analytic chemical analysis for the causal agent's determination. The determination was  carried out for the method of gas chromatography-mass spectrometry, in acids and basics urine extracts, for the confirmation of the diagnostic hypothesis. The results corroborated Carbamazepine as causal agent of intoxication, corresponding with the signs  and clinical symptoms experienced by the patient. It a treatment with general measures of support was applied being reported a satisfactory clinical evolution. Keywords: carbamazepine, intoxication, GC-MS.