Synthesis and preliminary biological evaluation of two new cacalol esters of Naproxen and Ibuprofen

The successful synthesis of two propionates Naproxen and Ibuprofen of the tricyclic terpenic phenol cacalol (Naproxen-cacalol and Ibuprofen-cacalol) is reported. Their NMR data, preliminary anti-inflammatory and analgesic evaluations, and molecular modelling are described. www.relaquim.com