Deposition of Air Particulate Matter in Human Respiratory System:a Review of Recent Studies

Exposure to air particulate matter has been associated with adverse health effects through inhalation.Particulate matter may deposit on the interfaces(such as nasal,oral,tracheobronchial,alveolar) due to inertial impaction,gravity,diffusion,etc.Deposition,clearance,translocation,and retention comprise the essential elements of dosimetry.Deposition connects the external exposure with internal exposure,providing a scientific basis for further research on dose-response relationship and toxic mechanisms.This review focused on the characteristics of deposition in the human respiratory system,mainly including deposition mechanisms,impact factors and deposition models.Also,the problems existing in previous studies and the aspects of further research were proposed in this review.