Compositions and methods for generating an immune response to lasv

Compositions and methods are described for generating an immune response to an arenavirus. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to a member of genus Arenavirus (such as a member of species Lassa virus ) in the subject to which the vector is administered. The compositions and methods of the present invention may be used to prevent and/or treat an infection caused by arenavirus.