[Experimental studies of anti-proliferative effects of marinesponge extracts S1 - S3 on human lung adenocarcinoma and hepatocarcinoma cells].

OBJECTIVE: To study the anti-proliferative effects of marinesponge extract-S1 - S3 on human lung adenocarcinoma GLC-82, hepatocarcinoma 7402 and gastric carcinoma MCG-803 cells in vitro. METHODS: The parameters were got by MTT assay. RESULTS: After human lung adenocarcinoma GLC-82, hepatocarcinoma 7402 and gastric carcinoma MCG-803 cells were treated by marinesponge extract-S1 - S3 for 48h, the growth of lung adenocarcinoma GLC-82 and hepatocarcinoma 7402 cells were inhibited significantly by the S3 and the IC50 were 2. 714 microg/ml and 2. 598 microg/ml respectively; but no significant effect on the gastric carcinoma MCG-803 cells. The marinesponge extracts S1 and S2 don't show inhibitive effect on the proliferation of those three tumor cells. CONCLUSION: Marine-sponge extract S3 can inhibit the proliferation of lung adenocarcinoma GLC-82 and hepatocarcinoma 7402 cells significantly.